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48 These translocations may well take place during the context of intricate karyo styles. The most common rearrangements require 13q14, with numerous companions, as well as the IGH locus. The genes most often rearranged with IGH are BCL2
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102 Conversely, several teams are advocating with the incorporation of novel markers, for instance a advanced karyotype55 or epigenetic subsets, 27,28 into scientific exercise. All of these novel prognostic and/or predictive styles will must be validated in cohorts of sufferers taken care of with focused agents.
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